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Visual Treats in Dermatology
2022
:2;
38
doi:
10.25259/CSDM_34_2022

Dyschromatosis universalis hereditaria (DUH)

Department of Dermatology, AIIMS Rishikesh, Uttarakhand, India
Corresponding author: Anmol Batra, Department of Dermatology, AIIMS Rishikesh, Uttarakhand, India. anmolbatra9@gmail.com
Licence
This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Batra A, Hazarika N. Dyschromatosis universalis hereditaria (DUH). CosmoDerma 2022;2:38.

A 41-year-old male presented to us with multiple asymptomatic hypopigmented, and hyperpigmented skin lesions all over the body since the age of 5 years. The lesions had started over the abdomen and gradually spread toward other body parts over the duration of the next 3 years. There was no history of photosensitivity or any drug intake or handling of any chemical. No one in the family had similar complaints. On cutaneous examination, there was diffuse hyperpigmentation interspersed with spotty and reticulate hypopigmented macules (giving a mottled appearance) of irregular size and shape over the trunk and limbs relatively sparing bilateral axilla and inguinal folds [Figure 1a-e]. Keratotic follicular papules, suggestive of keratosis pilaris [Figure 1c-e], were also seen on the posteromedial aspects of the arms and anterior aspects of the thighs. There were concomitant unrelated tinea corporis plaques [Figure 1e] on the medial aspect of the thighs as well. His palms, soles, and mucous membranes were within normal limits. Based on these findings, a diagnosis of dyschromatosis universalis hereditaria (DUH) was made. The patient was counseled regarding the unremitting, but benign nature of DUH.

Figure 1:: (a and b) Dyschromasia—diffuse and spotty hyperpigmentation interspersed with spotty and reticulate hypopigmented macules of irregular size and shape over the trunk (c and d) limbs relatively sparing bilateral axilla (e) inguinal folds.

Dyschromatosis universalis hereditaria is a rare autosomal genodermatosis. It was first described in 1929 in Japan. It is classified into three subtypes. DUH1-an autosomal dominant disease with linkage to 6q24.2-q25.2.[1] DUH2-autosomal recessive disease mapped to 12q21- q23.[2] DUH3-heterozygous mutation in the ABCB6 gene on chromosome 2q35.[3] DUH has been associated with neurological, ophthalmological, and hematological complications.[2]

Declaration of patient consent

Patient’s consent is not required as patient’s identity is not disclosed or compromised.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

  1. , , , , , , et al. Mutations of the RNA-specific adenosine deaminase gene (DSRAD) are involved in dyschromatosis symmetrica hereditaria. Am J Hum Genet. 2003;73:693-9.
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  2. , , , , , , et al. Dyschromatosis universalis hereditaria: evidence for autosomal recessive inheritance and identification of a new locus on chromosome 12q21-q23. Clin Genet. 2008;73:566-72.
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  3. , , , , , , et al. Mutations in ABCB6 cause dyschromatosis universalis hereditaria. J Invest Dermatol. 2013;133:2221-8.
    [CrossRef] [PubMed] [Google Scholar]

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