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Visual Treats in Dermatology
2021
:1;
58
doi:
10.25259/CSDM_62_2021

Acral acanthosis nigricans may be a marker of internal malignancy

Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India
Corresponding author: Arunachalam Narayanan, Department of Dermatology and STD, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India. narayanan359@gmail.com
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This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Narayanan A, Anurag SV. Acral acanthosis nigricans may be a marker of internal malignancy. CosmoDerma 2021;1:58.

A 34-year-old male patient, a known case of ileal carcinoid tumor with secondaries in the liver (since 2013) presented with asymptomatic, symmetrical, velvety, and black patches over the dorsum of metacarpophalangeal, metatarsophalangeal, and interphalangeal joints of hands and feet [Figure 1], with sparing of axillary folds, other intertriginous areas and palms for the past 1 year or so. Histopathological examination of skin biopsy from dorsum of hand revealed epidermal hyperkeratosis and papillomatosis, findings consistent with acanthosis nigricans. Based on the history, examination, and typical histopathological findings, a diagnosis of acral malignant acanthosis nigricans was made. Acral acanthosis nigricans is thought to be more common in dark complexion races with no association with systemic diseases. It has been reported with dermatofibrosarcoma protuberans, non-Hodgkin’s lymphoma, and gastric adenocarcinoma.[1] In the present case, acral-type acanthosis nigricans was accompanied by the presence of rare ileal carcinoid tumor.

Figure 1:: Bilateral symmetric velvety black patches over the dorsum of metacarpophalangeal, metatarsophalangeal, and interphalangeal joints of hands and feet.

Declaration of patient consent

Patient’s consent not required as patient’s identity is not disclosed or compromised.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

References

  1. , , , , . Acral acanthosis nigricans (acral acanthotic anomaly) Indian Dermatol Online J. 2014;5:140-1.
    [CrossRef] [PubMed] [Google Scholar]

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