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Visual Treats in Dermatology
2023
:3;
131
doi:
10.25259/CSDM_163_2023

Acquired epidermodysplasia verruciformis

Department of Dermatology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India
Corresponding author: Arun Somasundaram, Department of Dermatology, KMCH Institute of Health Sciences and Research, Coimbatore, Tamil Nadu, India. arunsomasundaram25@gmail.com
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This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-Share Alike 4.0 License, which allows others to remix, transform, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

How to cite this article: Somasundaram A, SakkaravarthiV. Acquired epidermodysplasia verruciformis. CosmoDerma 2023;3:131.

A 40-year-old male patient known case of undifferentiated connective tissue disease with secondary antiphospholipid antibody syndrome on azathioprine and hydroxychloroquine presented with asymptomatic skin lesions over the neck and upper chest for the past 1 month. Cutaneous examination revealed multiple discrete hypopigmented macules over the neck and upper chest [Figure 1a]. Palms, soles, oral cavity, nails, and genitalia did not reveal any abnormalities. Differentials of tinea versicolor, verruca plana, and epidermodysplasia verruciformis were considered. Potassium hydroxide mount did not suggest findings of tinea versicolor. Skin biopsy from the upper chest revealed an ortho keratotic thickened epidermis with pale blue-gray keratinocytes in the granular layer as well as a spinous layer compatible with epidermodysplasia verruciformis [Figure 1b and c].

Figure 1:
(a) Multiple discrete hypopigmented macules over the neck and upper chest. (b) Ortho keratotic thickened epidermis with pale blue-gray keratinocytes in the granular layer as well as a spinous layer (H&E, ×200). (c) A closer view of pale blue-gray keratinocytes (H&E, ×400).

The patient was advised topical retinoids for the same and was asked to follow-up after a month.

Epidermodysplasia verruciformis is an inherited genodermatosis with increased susceptibility to human papillomavirus infection resulting in benign and malignant changes that feature both viral oncogenesis and immunosuppression. Acquired forms occur in the setting of underlying immunosuppression, connective tissue disease, lymphomas, or any immunosuppressive drugs.[1] Cutaneous features seen include flat-topped papules, tinea versicolor-like lesions, and papillomatous, reddish-brown pigmented plaques over the face, and trunk. Malignant transformation can occur in 30–50% of individuals.[1] The treating clinicians need to be aware of this entity and the need for long-term follow-up in such individuals. Management options include topical retinoids, 5-fluorouracil, and imiquimod, and in extensive skin lesions, systemic retinoids have been advocated with variable results along with photoprotection.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent.

Conflicts of interest

There are no conflicts of interest.

Use of artificial intelligence (AI)-assisted technology for manuscript preparation

The authors confirm that there was no use of artificial intelligence (AI)-assisted technology for assisting in the writing or editing of the manuscript and no images were manipulated using AI.

Financial support and sponsorship

Nil.

References

  1. , , , . Acquired epidermodysplasia verruciformis during highly active antiretroviral therapy. Indian J Dermatol. 2022;67:316.
    [CrossRef] [PubMed] [Google Scholar]

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